Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels
نویسندگان
چکیده
منابع مشابه
Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels
All cells contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, sy...
متن کاملOxidative Regulation of Large Conductance Calcium-Activated Potassium Channels
Reactive oxygen/nitrogen species are readily generated in vivo, playing roles in many physiological and pathological conditions, such as Alzheimer's disease and Parkinson's disease, by oxidatively modifying various proteins. Previous studies indicate that large conductance Ca(2+)-activated K(+) channels (BK(Ca) or Slo) are subject to redox regulation. However, conflicting results exist whether ...
متن کاملShear stress and intermediate-conductance calcium-activated potassium channels.
Vascular endothelial cells (EC) are continuously exposed to shear stress associated with the flowing blood. Over the years, it has become clear that such shear exerts a multitude of effects on endothelial biology and vascular function and structure, ranging in time span from seconds to months. On the scale of seconds, shear-dependent vasodilation has been demonstrated in many experimental setti...
متن کاملRegulation of large conductance calcium- and voltage-activated potassium (BK) channels by S-palmitoylation.
BK (large conductance calcium- and voltage-activated potassium) channels are important determinants of physiological control in the nervous, endocrine and vascular systems with channel dysfunction associated with major disorders ranging from epilepsy to hypertension and obesity. Thus the mechanisms that control channel surface expression and/or activity are important determinants of their (path...
متن کاملBK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing.
Ion channels and lipid phosphatases adopt a transmembrane voltage sensor domain (VSD) that moves in response to physiological variations of the membrane potential to control their activities. However, the VSD movements and coupling to the channel or phosphatase activities may differ depending on various interactions between the VSD and its host molecules. BK-type voltage, Ca²(+) and Mg²(+) acti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomolecules
سال: 2015
ISSN: 2218-273X
DOI: 10.3390/biom5031870